Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons
نویسندگان
چکیده
منابع مشابه
Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons.
Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma memb...
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The effects of membrane-permeant Ca2+ chelators on field EPSPs (fEPSPs) were measured in the hippocampal CA1 region of brain slices from young (2-4 months) and old (24-27 months) Fischer 344 rats. BAPTA-AM depressed fEPSPs in young slices by up to 70% but enhanced fEPSPs by 30% in aged slices. EGTA-AM, with slower binding kinetics, did not affect fEPSPs from young slices but enhanced fEPSPs in ...
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Initial velocities of energy-dependent Ca(++) uptake were measured by stopped-flow and dual-wavelength techniques in mitochondria isolated from hearts of rats, guinea pigs, squirrels, pigeons, and frogs. The rate of Ca(++) uptake by rat heart mitochondria was 0.05 nmol/mg/s at 5 microM Ca(++) and increased sigmoidally to 8 nmol/mg/s at 200 microM Ca(++). A Hill plot of the data yields a straigh...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2007
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2007.03.005